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Applikon Micro-Flask

Reproducible cultivation in microtiter plates

An easy-to-use, and cost-effective technology platform for the rapid handling and growth of large numbers of microbial strains, clonal libraries, mutant banks, and cell lines. This system enables a single person to grow and test thousands of strains simultaneously with a minimum of repetitive handlings.

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Your interest in bioreactor systems

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Argentina

Hixwer 
Phone: +54 11 7078-6666
Email: info@hixwer.com
URL: www.hixwer.com

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Argentina

Hixwer 
Phone: +54 11 7078-6666
Email: info@hixwer.com
URL: www.hixwer.com

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Brazil

Sotelab
+55 (21) 3392-3563
www.sotelab.com.br

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Brazil

Sotelab
+55 (21) 3392-3563
www.sotelab.com.br

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Chile, Peru

AP Bioprocess
www.ap-bioprocess.com

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Chile, Peru

AP Bioprocess
www.ap-bioprocess.com

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Colombia

Intek Group
Phone: +57 316 3550400 - 749 8437
Email: contacto@intekgroup.com.co
URL: www.intekgroup.com.co

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Colombia

Intek Group
Phone: +57 316 3550400 - 749 8437
Email: contacto@intekgroup.com.co
URL: www.intekgroup.com.co

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Czech Republic

Vekamaf
Phone: +420 284 690 881
URL: www.vekamaf.cz

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Czech Republic

Vekamaf
Phone: +420 284 690 881
URL: www.vekamaf.cz

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Denmark

Holm & Halby
Phone: +454326 9400
Email: info@holm-halby.dk
URL: www.holm-halby.dk

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Denmark

Holm & Halby
Phone: +454326 9400
Email: info@holm-halby.dk
URL: www.holm-halby.dk

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Estonia

Bio Techa
Phone: +372 6597101
Email: info@biotecha.ee
URL: www.biotecha.lt

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Estonia

Bio Techa
Phone: +372 6597101
Email: info@biotecha.ee
URL: www.biotecha.lt

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Hungary

Holimex
Phone: +36 1 391 4400
URL: www.holimex.hu

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Hungary

Holimex
Phone: +36 1 391 4400
URL: www.holimex.hu

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India

Spinco Biotech Pvt. Ltd.
Phone: +91 44 45678900
Email: info@spincotech.com
URL: www.spincotech.com

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India

Spinco Biotech Pvt. Ltd.
Phone: +91 44 45678900
Email: info@spincotech.com
URL: www.spincotech.com

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Indonesia

PT Arico Sainsindo Nusantara
Phone: +62-21 580 6342 / 3
Email: arico@dnet.net.id
URL: www.ptarico.com

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Indonesia

PT Arico Sainsindo Nusantara
Phone: +62-21 580 6342 / 3
Email: arico@dnet.net.id
URL: www.ptarico.com

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Ireland

Asistec
Phone: +353(0)1286 8796
Email: info@asistec.ie
URL: www.asistec.ie

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Ireland

Asistec
Phone: +353(0)1286 8796
Email: info@asistec.ie
URL: www.asistec.ie

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Israel

Medent Group
Phone: +97286237984
Email: info@medent.co.il
URL: medent.co.il

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Israel

Medent Group
Phone: +97286237984
Email: info@medent.co.il
URL: medent.co.il

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Italy

Steroglass
Phone: +39 075 609091
Email: info@steroglass.it 
URL: www.steroglass.it

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Italy

Steroglass
Phone: +39 075 609091
Email: info@steroglass.it 
URL: www.steroglass.it

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Japan

Sanyo Trading Co., LTD
Phone: +81-3-3518-1196
URL: www.sanyo-trading.co.jp

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Japan

Sanyo Trading Co., LTD
Phone: +81-3-3518-1196
URL: www.sanyo-trading.co.jp

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Lithuania

Bio Techa
Phone: +370 5 237 60 07
Email: info@biotecha.lt
URL: www.biotecha.lt

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Lithuania

Bio Techa
Phone: +370 5 237 60 07
Email: info@biotecha.lt
URL: www.biotecha.lt

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Norway

Bio Nordica
Phone: 23 03 58 00
Email: info@bionordika.no
URL: bionordika.no

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Norway

Bio Nordica
Phone: 23 03 58 00
Email: info@bionordika.no
URL: bionordika.no

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Poland

Labo Baza
Phone: +4861 812 57 45
Email: biuro@labobaza.pl
URL: www.labobaza.pl

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Poland

Labo Baza
Phone: +4861 812 57 45
Email: biuro@labobaza.pl
URL: www.labobaza.pl

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Portugal

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

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Portugal

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

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Russia

Abtek
Phone: +7(495) 723-64-97
Email: abtek@abtek.ru
URL: abtek.ru

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Russia

Abtek
Phone: +7(495) 723-64-97
Email: abtek@abtek.ru
URL: abtek.ru

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Singapore

Zil Sci Pte. Ltd.
Phone: +65 6767 2929
Email: ENQUIRY@ZILSCI.COM
URL: www.zilsci.com

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Singapore

Zil Sci Pte. Ltd.
Phone: +65 6767 2929
Email: ENQUIRY@ZILSCI.COM
URL: www.zilsci.com

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Slovakia

Vekamaf
Phone: +421-2-52932891
URL: www.vekamaf.cz

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Slovakia

Vekamaf
Phone: +421-2-52932891
URL: www.vekamaf.cz

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South Africa

Seperations
Phone: +27 11 919 1000
Email: info@separations.co.za
URL: separations.co.za

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South Africa

Seperations
Phone: +27 11 919 1000
Email: info@separations.co.za
URL: separations.co.za

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South Korea

SeouLin Bioscience
Phone: +821670-5911
Email: support@seoulin.co.kr
URL: www.seoulin.co.kr

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

South Korea

SeouLin Bioscience
Phone: +821670-5911
Email: support@seoulin.co.kr
URL: www.seoulin.co.kr

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Spain

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Spain

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Switzerland

Resea Biotec
Phone: +41 34 531 08 20
Email: office@reseabiotec.ch
URL: www.reseabiotec.ch

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Switzerland

Resea Biotec
Phone: +41 34 531 08 20
Email: office@reseabiotec.ch
URL: www.reseabiotec.ch

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Taiwan

Tseng Hsiang Life Science Ltd.
Phone: +862-27851156
Email: info@thco.com.tw
URL: www.thco.com.tw

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Taiwan

Tseng Hsiang Life Science Ltd.
Phone: +862-27851156
Email: info@thco.com.tw
URL: www.thco.com.tw

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Meditop Co., Ltd

Holm & Halby
Phone: +662 9331133
Email: info@meditopthailand.com
URL: meditopthailand.com

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Meditop Co., Ltd

Holm & Halby
Phone: +662 9331133
Email: info@meditopthailand.com
URL: meditopthailand.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Turkey

Ant Teknik
Phone: +90 216 422 6700
Email: antteknik@antteknik.com 
URL: www.antteknik.com

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Turkey

Ant Teknik
Phone: +90 216 422 6700
Email: antteknik@antteknik.com 
URL: www.antteknik.com

The Applikon Micro-Flask with various configurations of cover clamps and sandwich covers
The Applikon Micro-Flask by Duetz design

Speed up your process by cultivating strains in parallel

  • Low and uniform evaporation rates
  • Sterile barrier for individual wells prevents cross contamination
  • Oxygen transfer rates similar to shake flasks in standard orbital shakers
  • Conversion of 24 and 96 microtiter plates (both deep and low-well plates) into individual micro-bioreactors
  • Simultaneous and reproducible sampling of 96 frozen glycerol stocks using our Cryo-Replicator

All handling with the Micro-Flask is performed in parallel with sets of 24 or 96 strains. It provides a more efficient use of your current orbital shaker, with time savings up to a factor 10 possible. It allows for the same quality of growth as in Erlenmeyer flasks in terms of oxygen transfer rates and reproducibility.

Related products

Individual micro-reactors

The Micro-Flask turns 6, 24 and 96-well microtiter plates into individual micro-reactors enabling simultaneous and reproducible cultivations.

Transfer of oxygen

The oxygen transfer in the Micro-Flask is similar to fermenters enabling accurate cultivations.

Specifications

Type of
microtiter plate
Well volume Culture volume Orbital shaking frequency Shaking amplitude O2-transfer rate
(30˚C, air, 1 bar)
Headspace refreshment rate Evaporation rate per well
(at 30˚C)
Mixing pattern
at 300 rpm
             

 

ampl.
25 mm
ampl.
50 mm
24-square deep-well
polypropylene,
17x17 mm,
depth 40 mm
11000 µL 2500 µL 300 rpm 50 mm 51 mmol O2/l/h 2.5 mL / min
(1 VVM)

50% humidity:
50 µL H2O per day

75% humidity:
25 µL H2O per day

2500 µL 2500 µL
2500 µL 300 rpm 25 mm 39 mmol O2/l/h
2500 µL 220 rpm 50 mm 35 mmol O2/l/h
         
4000 µL 300 rpm 50 mm 24 mmol O2/l/h 2.5 mL / min
(0.6 VVM)
4000 µL 220 rpm 25 mm 24 mmol O2/l/h
24-round low-well
polystyrene, ⌀16 mm,
depth 18 mm
3000 µL 750 µL 300 rpm 50 mm 40 mmol O2/l/h 1.1 mL / min
(1.4 VVM)

50% humidity:
30 µL H2O per day

75% humidity:
15 µL H2O per day

1000 µL 1000 µL
750 µL 300 rpm 25 mm 25 mmol O2/l/h
         
1000 µL 300 rpm 50 mm 30 mmol O2/l/h 1.1 mL / min
(1.1 VVM)
1000 µL 300 rpm 25 mm 19 mmol O2/l/h
96-square deep-well
polypropylene,
8x8 mm,
depth 40 mm
2400 µL 500 µL 300 rpm 50 mm 38 mmol O2/l/h 1 mL / min
(2 VVM)

50% humidity:
22 µL H2O per day

75% humidity:
11 µL H2O per day

750 µL 750 µL
500 µL 300 rpm 25 mm 12 mmol O2/l/h
         
750 µL 300 rpm 50 mm 24 mmol O2/l/h 1 mL / min
(1.3 VVM)
750 µL 300 rpm 25 mm 7 mmol O2/l/h
         
1000 µL 300 rpm 50 mm 18 mmol O2/l/h 1 mL / min
(1 VVM)
1000 µL 300 rpm 25 mm 3 mmol O2/l/h
96-round low-well
polystyrene,
⌀6.5 mm,
depth 11 mm
380 µL 100 µL 300 rpm 50 mm 39 mmol O2/l/h 250 µL / min
(2.5 VVM)

50% humidity:
6 µL H2O per day

75% humidity:
3 µL H2O per day

150 µL 150 µL
100 µL 300 rpm 25 mm 20 mmol O2/l/h
         
150 µL 300 rpm 50 mm 32 mmol O2/l/h 250 µL / min
(1.7 VVM)
150 µL 300 rpm 25 mm 16 mmol O2/l/h
         
200 µL 220 rpm 50 mm 12 mmol O2/l/h 250 µL / min
(1.3 VVM)
200 µL 300 rpm 25 mm 12 mmol O2/l/h