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ISOTEST Isolators

Efficient and reliable sterility testing processes

Getinge ISOTEST is an isolator designed for sterility testing of sterile drugs, components, and devices. Continuous workflow, easy access, and fast bio-decontamination help increase productivity.

A 6-glove double workstation ISOTEST isolator with a hatch and two DPTE® Alpha rapid transfer ports

Two-person isolator for optimized workflows

  • Double work station
  • Increased productivity
  • Effective bio-decontamination
  • Validated process control
  • Full traceability
 

Optimize your sterility testing workflows

Sterility testing is the last mandatory control performed on sterile drugs before their release to patients. It must be performed inside a controlled sterile environment to avoid the risk of false-positive results.

The ISOTEST isolator is a completely closed system providing a controlled environment and optimal workflows for reliable sterility testing. Compared to a cleanroom, isolators provide a smaller and simpler environment to be controlled. Sources of contamination can be detected immediately for greater control over process parameters and easier traceability.

The ISOTEST isolator facilitates a continuous testing process instead of a batch process, eliminating unproductive time between batches.

Watch the video to view the ISOTEST used for sterility testing.

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Two operators working simultaneously in the ISOTEST isolator

Optimized workflow

Dual-operator access

The Getinge Isotest system design is optimized for sterility testing procedures. Two operators can have good simultaneous access to the chamber. This allows them to work simultaneously with the same or different sterility testing methods inside the isolator.

The system can be used with any combination of closed or open membrane filtration, direct inoculation methods, and rapid microbiology methods (RMM). 

An operator working in the ISOTEST isolator

Improved throughput

Minimize downtime

The Getinge Isotest isolator facilitates a continuous testing process instead of a batch process, eliminating unproductive time between batches.

Short bio-decontamination cycles and the capacity for dual operations combine for a throughput rate of up to 40 tests per 8-hour shift.*

* Based on an average test size on 20 ml containers/vials

A 6-glove double workstation ISOTEST isolator with a hatch and two DPTE® Alpha rapid transfer ports

Validated process control

Traceability

Both the isolator and integral bio-decontamination unit are controlled by a single Siemens PLC control system. The control system monitors and records process-critical parameters that can be sent to a printer, remote PC (option); or stored in the customer network through SCADA integration (option).

A color touchscreen control panel is intuitive and easy to operate. Through the HMI, authorized users can set process parameters that operators can easily monitor during the process.

An operator loading the ISOTEST's hatch

Effective bio-decontamination

The ISOTEST isolator offers the possibility to bio-decontaminate the total volume of the unit; the hatch can be included, or bio-decontaminated separately.  Bio-decontamination of the load within the hatch occurs quickly for high productivity — often within 30-45 minutes.

The integrated bio-decontamination unit uses hydrogen peroxide (H2O2) vapor (HPV) as sterilant. The generator is controlled by the same PLC as the unit, providing reliable operations.

DPTE-BetaBag® for efficient waste handling

Safe and efficient waste handling

A dual-waste DPTE-BetaBag® allows for safe removal of liquid and solid waste from the isolator.

The DPTE® system provides egress from inside the isolator chamber while maintaining isolator integrity; there is no risk of sample or environmental contamination.

Sterile applications

The ISOTEST is a multipurpose solution used in various aseptic applications.

Operator performing aseptic manipulation in an ISOTEST isolator
  • Sterility testing or quality control (membrane filtration, direct inoculation, rapid method)
  • Transfer or Biodecontamination isolator (can be mobile)
  • Aseptic processing (assembly of processes, parts preparation, etc.)
  • Transfer, repacking of sterile components, closures, etc.
  • Reactor or vessel charging isolator
  • Assembly, preparation of medical devices
  • Compounding (Total Parenteral Nutrition TPN, Intravenous IV solution, cytotoxic reconstitution…)
  • Cell culture, cell & gene therapy
  • Personalized medicine
  • Etc.

Accessories for ISOTEST isolators