Ease your process with single-use
- Low risk of operator exposure
- No risk of cross-contamination between products
- Click-n-Go bag loading for easy use
- Save time on cleaning and validation procedures
- All-in-one single-use cultivation container for fast start-up and changeover
SUPR design. SUPR scalable. SUPR simple.
Our Single-Use Production Reactor offers all benefits of single-use bioprocessing and allows for a smooth transfer from lab-scale to production-scale with one common single-use platform.
Watch the video to discover how the SUPR offers the flexibility and scalability that you need.
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SUPR simple
THe SUPR arrives sterilized, assembled, and ready to use. The SUPR materials are fully qualified for biological product contact per USP Class VI plastics. Each assembly is manufactured and documented under cGMP conditions. No cleaning or sterilization validations are required as the SUPR C3 comes gamma irradiated.
The SUPR holder enables easy installation with an innovative click and lock system for the motor and an intuitive tube management system.
SUPR scalable
The SUPR system is designed to be a single-use alternative to traditional stainless steel tank bioreactors at both pilot and production scale. Starting with AppliFlex ST, the SUPR now makes it possible to continue cultivation with one trusted portfolio. R&D and process optimization performed in the AppliFlex ST can now be easily scaled up using the SUPR.
SUPR supports flexible volumes with both 50- and 250-liter containers available now and a 1000-liter container upcoming in future.
SUPR design
The SUPR is part of our comprehensive portfolio that takes you all the way from research to production. The SUPR design is based on more than five decades of bioprocessing experience and includes a height adjustable impeller along with typical Applikon design parameters such as height-to-diameter ratios and a dished bottom.
Specifications
50 L |
250 L |
|
| Total volume (L) | 71 | 356 |
| Working volume (L) | 50 | 250 |
| Minimum working volume (L) | 10 | 50 |
| Aspect ratio total volume | 1.7 | 1.7 |
| Aspect ratio working volume | 1.24 | 1.23 |
| Bottom | Dished bottom | Dished bottom |
| Impellers | Marine with 152 mm diameter | Marine with 260 mm diameter |
| Sparger | Drilled hole sparger | Drilled hole sparger |
| Ports | • 1 X Sample port + Temperature pocket • 1 X single-use Optical DO sensor InSUS 607 Mettler Toledo • 1 X single-use pH sensor InSUS 310 Mettler Toledo |
• 1 X Sample port + Temperature pocket • 1 X single-use Optical DO sensor InSUS 607 Mettler Toledo • 1 X single-use pH sensor InSUS 310 Mettler Toledo |
| Special port | • 1x Drain to Bottom port with CPC MPX 1/2" connector | • 1x Drain to Bottom port with CPC MPX 3/4" connector |
| Sterilization | >25 kGy Gamma irradiation | >25 kGy Gamma irradiation |
The SUPR is ideal for the following applications:
- Cell and gene therapies
- mABs
- Vaccines
- Diagnostics
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The single-use production reactor system for bioprocesses at pilot- and production scale
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Single-Use Production Reactor (SUPR) for CGT, monoclonal antibodies, vaccines and more...
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