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Applikon BioSep

Perfusión escalable de cultivos celulares

El Applikon BioSep es un dispositivo de retención celular único para el proceso de alimentación constante de medios frescos y eliminación de medios gastados, a la vez que retiene un alto número de células viables. Utiliza ondas ultrasónicas resonantes de alta frecuencia para separar las células y, por lo tanto, elimina automáticamente los residuos celulares, lo que lo convierte en la solución perfecta para bioprocesos continuos.

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Your interest in bioreactor systems

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Argentina

Hixwer 
Phone: +54 11 7078-6666
Email: info@hixwer.com
URL: www.hixwer.com

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Argentina

Hixwer 
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Email: info@hixwer.com
URL: www.hixwer.com

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Brazil

Sotelab
+55 (21) 3392-3563
www.sotelab.com.br

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Brazil

Sotelab
+55 (21) 3392-3563
www.sotelab.com.br

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Chile, Peru

AP Bioprocess
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Chile, Peru

AP Bioprocess
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Colombia

Intek Group
Phone: +57 316 3550400 - 749 8437
Email: contacto@intekgroup.com.co
URL: www.intekgroup.com.co

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Colombia

Intek Group
Phone: +57 316 3550400 - 749 8437
Email: contacto@intekgroup.com.co
URL: www.intekgroup.com.co

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Czech Republic

Vekamaf
Phone: +420 284 690 881
URL: www.vekamaf.cz

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Czech Republic

Vekamaf
Phone: +420 284 690 881
URL: www.vekamaf.cz

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Denmark

Holm & Halby
Phone: +454326 9400
Email: info@holm-halby.dk
URL: www.holm-halby.dk

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Denmark

Holm & Halby
Phone: +454326 9400
Email: info@holm-halby.dk
URL: www.holm-halby.dk

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Estonia

Bio Techa
Phone: +372 6597101
Email: info@biotecha.ee
URL: www.biotecha.lt

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Estonia

Bio Techa
Phone: +372 6597101
Email: info@biotecha.ee
URL: www.biotecha.lt

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Hungary

Holimex
Phone: +36 1 391 4400
URL: www.holimex.hu

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Hungary

Holimex
Phone: +36 1 391 4400
URL: www.holimex.hu

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India

Spinco Biotech Pvt. Ltd.
Phone: +91 44 45678900
Email: info@spincotech.com
URL: www.spincotech.com

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India

Spinco Biotech Pvt. Ltd.
Phone: +91 44 45678900
Email: info@spincotech.com
URL: www.spincotech.com

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Indonesia

PT Arico Sainsindo Nusantara
Phone: +62-21 580 6342 / 3
Email: arico@dnet.net.id
URL: www.ptarico.com

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Indonesia

PT Arico Sainsindo Nusantara
Phone: +62-21 580 6342 / 3
Email: arico@dnet.net.id
URL: www.ptarico.com

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Ireland

Asistec
Phone: +353(0)1286 8796
Email: info@asistec.ie
URL: www.asistec.ie

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Ireland

Asistec
Phone: +353(0)1286 8796
Email: info@asistec.ie
URL: www.asistec.ie

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Israel

Medent Group
Phone: +97286237984
Email: info@medent.co.il
URL: medent.co.il

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Israel

Medent Group
Phone: +97286237984
Email: info@medent.co.il
URL: medent.co.il

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Italy

Steroglass
Phone: +39 075 609091
Email: info@steroglass.it 
URL: www.steroglass.it

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Italy

Steroglass
Phone: +39 075 609091
Email: info@steroglass.it 
URL: www.steroglass.it

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Japan

Sanyo Trading Co., LTD
Phone: +81-3-3518-1196
URL: www.sanyo-trading.co.jp

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Japan

Sanyo Trading Co., LTD
Phone: +81-3-3518-1196
URL: www.sanyo-trading.co.jp

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Lithuania

Bio Techa
Phone: +370 5 237 60 07
Email: info@biotecha.lt
URL: www.biotecha.lt

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Lithuania

Bio Techa
Phone: +370 5 237 60 07
Email: info@biotecha.lt
URL: www.biotecha.lt

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Norway

Bio Nordica
Phone: 23 03 58 00
Email: info@bionordika.no
URL: bionordika.no

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Norway

Bio Nordica
Phone: 23 03 58 00
Email: info@bionordika.no
URL: bionordika.no

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Poland

Labo Baza
Phone: +4861 812 57 45
Email: biuro@labobaza.pl
URL: www.labobaza.pl

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Poland

Labo Baza
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Portugal

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

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Portugal

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

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Russia

Abtek
Phone: +7(495) 723-64-97
Email: abtek@abtek.ru
URL: abtek.ru

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Russia

Abtek
Phone: +7(495) 723-64-97
Email: abtek@abtek.ru
URL: abtek.ru

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Singapore

Zil Sci Pte. Ltd.
Phone: +65 6767 2929
Email: ENQUIRY@ZILSCI.COM
URL: www.zilsci.com

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Singapore

Zil Sci Pte. Ltd.
Phone: +65 6767 2929
Email: ENQUIRY@ZILSCI.COM
URL: www.zilsci.com

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Slovakia

Vekamaf
Phone: +421-2-52932891
URL: www.vekamaf.cz

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Slovakia

Vekamaf
Phone: +421-2-52932891
URL: www.vekamaf.cz

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South Africa

Seperations
Phone: +27 11 919 1000
Email: info@separations.co.za
URL: separations.co.za

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South Africa

Seperations
Phone: +27 11 919 1000
Email: info@separations.co.za
URL: separations.co.za

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South Korea

SeouLin Bioscience
Phone: +821670-5911
Email: support@seoulin.co.kr
URL: www.seoulin.co.kr

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South Korea

SeouLin Bioscience
Phone: +821670-5911
Email: support@seoulin.co.kr
URL: www.seoulin.co.kr

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Spain

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

We have a local distributor for this country. Feel free to reach out directly via below phone number, email or website for quickest response.

Spain

Aplitech Biolab
Phone: +34 629818802
www.aplitechbiolab.com

 

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Switzerland

Resea Biotec
Phone: +41 34 531 08 20
Email: office@reseabiotec.ch
URL: www.reseabiotec.ch

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Switzerland

Resea Biotec
Phone: +41 34 531 08 20
Email: office@reseabiotec.ch
URL: www.reseabiotec.ch

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Taiwan

Tseng Hsiang Life Science Ltd.
Phone: +862-27851156
Email: info@thco.com.tw
URL: www.thco.com.tw

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Taiwan

Tseng Hsiang Life Science Ltd.
Phone: +862-27851156
Email: info@thco.com.tw
URL: www.thco.com.tw

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Meditop Co., Ltd

Holm & Halby
Phone: +662 9331133
Email: info@meditopthailand.com
URL: meditopthailand.com

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Meditop Co., Ltd

Holm & Halby
Phone: +662 9331133
Email: info@meditopthailand.com
URL: meditopthailand.com

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Turkey

Ant Teknik
Phone: +90 216 422 6700
Email: antteknik@antteknik.com 
URL: www.antteknik.com

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Turkey

Ant Teknik
Phone: +90 216 422 6700
Email: antteknik@antteknik.com 
URL: www.antteknik.com

The Applikon BioSep 50 liter perfusion device
The Applikon BioSep 10 liter perfusion device
The Applikon BioSep 1 liter perfusion device
Applikon BioSep

La solución ideal para el cultivo a largo plazo

  • Eliminación automática de los residuos celulares
  • No daña las células
  • La ausencia de suciedad o bloqueo permite un funcionamiento a largo plazo
  • Dispositivo de perfusión escalable (0,1-1000 l/día)

Alta eficiencia de separación

El uso de la tecnología de resonancia acústica permite una alta eficiencia de separación (99 %) sin dañar ninguna célula. Un modo de funcionamiento estándar emplea, por ejemplo, una bomba de recolección en el puerto de salida de la cámara del resonador y una bomba de recirculación para el retorno de células separadas que se asentaron desde el campo de energía acústica dentro de la cámara del resonador. Como alternativa, el sistema Applikon BioSep puede configurarse para permitir el funcionamiento semicontinuo o estrategias alternativas de recirculación celular.

Fácil de instalar y operar

El Applikon BioSep se puede montar directamente en la placa del cabezal del biorreactor. Una caracterización exhaustiva ha demostrado una escalabilidad completa entre los diferentes tamaños, lo que le permite comenzar en el modo de perfusión directamente al principio de la optimización del proceso, hasta la producción.
El sistema Applikon BioSep está disponible en 1 l/día, 10 l/día, 50 l/día, 200 l/día y 1000 l/día y es compatible con cualquier marca de biorreactor.

Probado en condiciones de cGMP

El sistema Applikon BioSep se usa como dispositivo de perfusión en varios procesos de cGMP operados comercialmente. El modelo de separación de 50 l/día y 200 l/día se suministra de forma predeterminada con toda la documentación y los servicios necesarios para el funcionamiento con cGMP.

Especificaciones técnicas

Sistema BioSep 1L 10L 50L 200L 1000L
Tasa de perfusión máxima 1 l/día 7 l/día 45 l/día 200 l/día 1000 l/día
Tasa de perfusión mínima 0,1 l/día    0,7 l/día 4,5 l/día 20 l/día 100 l/día
Eficiencia de separación Hasta un 99 % (en función de la concentración celular y el flujo de perfusión)
Concentración mínima de células 2 × 105 células/ml (en función del tamaño de la célula)
Conexión del biorreactor Tubo de 6 mm de DO Tubo de 12 mm de DO Se monta por separado Se monta por separado Se monta por separado
Entrada de medio Conector de manguera de 3 mm Conector de manguera de 6 mm Conector de manguera de 10 mm 0,5" TC 0,5" TC
Línea de retorno al biorreactor Conector de manguera de 3 mm Tubo de inmersión de 6 mm de OD 0,5" TC 0,5" TC 0,5" TC
Salida de perfusión Conector de manguera de 3 mm Conector de manguera de 6 mm Conector de manguera de 6 mm 0,5" TC 0,5" TC
Peso 0,1 kg 0,5 kg 1,5 kg 13 kg 70 kg
Volumen del resonador 0,7 ml 7 ml 50 ml 290 ml 1450 ml
           
Controlador BioSep APS 995 APS 990 APS 990 APS 992 APS 993
Alimentación del controlador BioSep 15 vatios 150 vatios 150 vatios 350 vatios 1500 vatios

Dimensiones del controlador BioSep

(largo × ancho × alto, mm)

En combinación con my-Control 305 × 130 × 130 305 × 130 × 130 450 × 400 × 135 450 × 300 × 450
Peso del controlador BioSep (kg) En combinación con my-Control 3,5 3,5 17,6 43