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Applikon MiniBio

The Applikon MiniBio is a true scale down of the classic laboratory scale bioreactor. It has the same flexibility, which means that the Applikon MiniBio can be customized to fit the demands of any process. The small volume reduces media costs and maximizes usage of bench space.

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The Applikon miniBio is a multi-use glass autoclavable bioreactor for small volume cultivations

The Applikon miniBio is a true scale down of the laboratory multi-use bioreactor

The Applikon miniBio system consisting of stirred tank bioreactor, controller and sensors

Real Small... Real Bioreactors

Easy set up and operation
Little bench space required
Less medium used during cultivation
Generate more data in less time

The MiniBio is the perfect device for small-scale operations in the lab. It saves time, takes up less bench space, and generates more data while providing fully scalable results. In combination with our highly efficient BioSep cell separation device, you can convert your batch or fed-batch bioreactor into a small scale continuous bioprocessing system.

The configurable head plate of the bioreactor has Luer fittings that free up space for multiple additions, sensors and fittings and ready-to-go tubing assemblies for a quick start.

Microbial and cell cultures at small scale

Sometimes less leads to more.
The Applikon MiniBio requires less medium and bench space than regular laboratory-scale bioreactors. Scientists can easily run multiple experiments in parallel, generating more data at once to enable efficient scale-up.

Watch the video to view how the MiniBio can speed up your bioprocess.

Small size bioreactors

The compact design of the MiniBio allows the scientist to place multiple systems on the valuable bench space. Parallel processing has never been that easy.

Generate scalable results

Running cultivations at small scale allows for quick access to more data. Scientists will have reliable data that simplifies scale-up to higher volumes.

Specifications

	MiniBio 250	MiniBio 500	MiniBio 1000
Total volume (mL)	290	550	1250
Working volume (mL)	200	400	1000
Minimum working volume (mL)	50	100	200
Aspect ratio total volume	2.3	2.1	2.3
Aspect ratio working volume	1.6	1.5	1.9
Dimensions (dxh)	180 x 400 mm	195 x 400 mm	200 x 550 mm
Dimensions for autoclaving (dxh)	180 x 250 mm	195 x 250 mm	200 x 400 mm
Drive system	Direct drive, lipsealed	Direct drive, lipsealed	Direct drive, lipsealed
Maximum stirrer speed (rpm)	50 - 2000	50 - 2000	50 - 1750
Maximum impeller tip speed (m/s)	2.3	2.9	3.5
Impellers	Choice of Rushton and Marine
Gas sparger	Porous sparger, open pipe sparger or jet sparger
Gas overlay	Yes
Exhaust gas	Electrically cooled exhaust gas condenser (evaporation <4% per day at 37°C @ 2vvm)
Sampling	Fixed sample pipe with optional sampling system
Draining	Height adjustable drain pipe
Additions	4 fixed inlet ports and optional micro liquid injectors
pH	Measurement: 8 mm classic pH sensor Control: via acid pump (variable speed pump) or CO2 gas in combination with alkali pump (variable speed pump)
DO2	Measurement: LumiSens Optical DO2 sensor. Control: via a combination of N2, Air, O2 (needle valve standard, MFC optional) and agitation
Temperature	Measurement: Pt-100 sensor in thermowell in topplate Control: electrical cooling and heating jacket via bioreactor wall
Foam	Measurement: Height adjustable conductivity based foam sensor Control: anti-foam addition (variable speed pump)
Level	Measurement: Height adjustable conductivity based level sensor Control: variable speed pump for liquid addition or removal
Optional inlets	Septum, chemostat tube, liquid entry system
Optional sensors	Biomass, Optical Density, O2 and CO2 off gas, weight balance

The Applikon MiniBio is ideal for the following applications:

Screening studies
Media optimization
Process optimization
Microbial and cell culture
Batch, Fed-Batch, Perfusion and Continuous cultivation

Applikon MiniBio

Your interest in bioreactor systems